There are naturally heavy chain antibodies (HCAb) that lack light chain and heavy chain CH1 structure but completely retain antigen binding activity in camelic animals such as alpacas. The variable region of heavy chain that specifically binds antigen is called single domain antibodies (sdAbs), or nanobody (VHH), which is the smallest unit antigen binding fragment.
Based on the flow cell sorting platform and DeepLight® screening platform, DetaiBio provides SingleB® Alpaca VHH Antibody Fast Discovery. The whole process from alpaca immunity, memory B cell and plasma cell double screening, BGE® high-throughput expression, expression identification to purification takes only 90 days, which saves at least 15 days compared with the display library.
Camelid heavy-chain antibody
Based on its structural specificity, VHH integrates the advantages of traditional antibodies and small molecule drugs:
90-day High Delivery
Deliver 50 FACs binders
& VHH sequence
double screening, double guarantee
with multiple on-chip assay
Higher antibody affinity
Basically eliminate immunogenicity
|Stage Ⅰ Animal Immunization||8-9 weeks||Premium Package|
|Stage Ⅱ “1+1”Double Screening||1 day|
|Stage Ⅲ BGE® HTP Expression & Functional Test||1-2 weeks|
|Stage Ⅳ Monoclonal Antibody Gene Sequencing||1 week|
Expression and Purification of Recombinant Antibody (optional)