Alpaca SingleB^® VHH Discovery Service

Based on its structural specificity, VHH integrates the advantages of traditional antibodies and small molecule drugs:

• Low Molecular Weight: only 12-14 kda with strong tissue penetration, widely used in tumor diagnosis and treatment and molecular imaging.
• Simple Structure: easy to carry out genetic engineering transformation, with 80% homology with human VH and easy to humanize.
• Low Immunogenicity: no FC tail end, which will not cause related immunogenicity, and has high pharmaceutical properties.
• High Specificity: long CDR3 region , which can form a finger shaped convex ring to further identify hidden antigen epitopes.
• High Hydrophilicity: hydrophilic amino acids in FR2 area ensure water solubility, and antibodies are not easy to aggregate.
• Simple Preparation: it can be expressed in large quantities, and the industrial scale-up production cost is low and the cycle is short.
• High Stability: it is easy to store and can withstand high temperature, strong acid, strong alkali and other mutagenic conditions.