Hapten Antibody Production Service
Immunoassay technology offers strong specificity, high sensitivity, high throughput, and rapid detection, making it a powerful tool in food safety testing and environmental pollutant detection in recent years.
Most toxins and environmental pollutants have a molecular mass of less than 1,000 Da, making them haptens, which possess immunoreactivity but lack immunogenicity. Their limited epitope diversity makes it challenging to produce high-affinity antibodies.
As a specialized hapten antibody CRO, DETAIBIO offers custom antibody production services for small molecules, from hapten design to recombinant antibody production. Our proprietary SingleB® Rapid Monoclonal Antibody Platform overcomes these limitations with high-throughput B cell screening, delivering antibodies with superior affinity and excellent detection sensitivity.
Application Areas
Our small molecule antibody development is widely applied in:
- Food Safety – Detection of harmful substances and veterinary drug residues
- Environmental Monitoring – Antibodies for pesticides, heavy metals, and industrial pollutants
- Clinical Diagnostics – Small molecule biomarker detection
- Forensic & Anti-Doping Testing – Identification of banned or illicit drugs
- Drug Development – Pharmacokinetics (PK) testing for small molecule drugs and ADC payloads
Workflow
| Service Stage | Service Details | Deliverables |
|---|
| Antigen Preparation (Optional) | - Hapten modification
- Hapten-carrier conjugation
| - 1-3 ELISA-positive clones
- Project report
|
| Animal Immunization | - Animal immunization
- Titer measurement
|
| B Cell Screening | |
| BGE® High-Throughput Expression & Functional Validation | |
| Recombinant Antibody Expression & Purification (Optional) | - Transfection-grade plasmid preparation
- transient expression & purification
| - 1 mg recombinant antibody
- Certificate of Analysis (CoA)
|
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